Newborns have a fragile and weak immune system during their first weeks. Their only defence comes from the colostrum delivered by the mom during the first hours after delivery.
Following an established disease-preventing course and schedule, tailored by your vet, will drastically increase your puppy’s chances to stay healthy during its first weeks.

DEWORMING

First parasites to eliminate: worms. They are actually not a huge threat, they do not want to kill, they simply want to use the puppy as a dinner plate.
Thriving in the dog’s intestines, the most common are the hookworms, roundworms, tapeworms and whipworms.
The American Association of Veterinary Parasitologists recommends the regular deworming of each puppy following a particular schedule, see the chart across, suitable for Panacur, the best wormer for dogs and cats, against all the above mentioned worms.
You can also give Panacur to the pregnant bitch few days before she gives birth: exact dosage on the very same chart

VACCINATION

A vaccination course is recommended to prevent a particular illness. They must be given by a professional following a particular timeline. The most convenient option is to use a multivalent vaccine to protect the puppy against multiple diseases in one injection.
DHLPPCV
You will come across this acronym DHLPPCv often if you get involved with puppies. It is a common multivalent vaccine that protects against: ● D – ​Distemper Virus​ – viral illness with no known cure ● H – ​Hepatitis​ – liver infection caused by two related viruses ● L – ​Leptospirosis​ – bacterial infection affecting kidneys ● P – ​Parainfluenza​ – upper respiratory viral infection in puppies ● P – ​Parvovirus​ – fatal virus affecting the intestinal linin● Cv – ​Coronavirus​ – similar to the Parvovirus but much less lethal

Visit your vet as soon as possible with the puppies so routine health checks can be performed and a precise schedule of preventive treatments can be discussed and thought-through.
In the meantime, a general schedule would be a first injection when the mom’s defense are disappearing from within the puppy at around 7-9 weeks. A second injection three weeks later at 12 weeks. A last one, not always recommended, after the 16th week.
The protection may vary depending on how much immunity has been passed on from the mother. Too much left might work against the vaccines and too little may require earlier vaccination.
The precise time a vaccine is the most effect Is when the mother’s immune protection is wearing off, it is also the moment the puppy is the most vulnerable to viruses and bacterias. If your puppy has unusual reaction after an injection, come back to to vet as soon as possible. These reactions include: unresponsiveness, pale gums, breathing troubled, staggers, etc